Homeopathic Research and Medically Oriented Sites

 

Sites with General Information:

1. The DigiBio Site
Dr. Jacques Benveniste’s observations of what has come to be known as «the memory of water» phenomenon, that is:

  • that water is capable of carrying molecular information (biological messages), and

  • that it is possible to transmit and amplify this information, as can be done for sounds and music”.

2. The Boiron Site
 


Ongoing Research in Homeopathy and Immunology 

1. The Biological Action of Dilutions of Aspirin, Professor DOUTREMEPUICH (University of Bordeaux, France)
In the past ten years, studies have been conducted in the Hematology Department of the School of Pharmacy of Bordeaux (France).

After having defined the validity and sensitivity of this experimental model, the authors conducted a comparative study on the effect of injecting several dilutions of aspirin.

  • area of thrombus provoked by arteriolar lesion and by venous lesion,

  • number of emboli induced by arteriolar lesion and by venous lesion,

  • length of embolization period induced by arteriolar lesion and by venous lesion,

  • amplitude and speed of platelet aggregation (in vitro).

2. The Synergistic Effects of Dilutions of Antitumoral Agents
Professor BONAVIDA (UCLA, USA)

Professor Bonavida's work consists in evaluating the toxicity of a certain number of substances used at concentrations below those at which their cellular toxicity has been demonstrated to date.
There are essentially four of these substances in question:

  • TNF Tumor Necrosis Factor

  • CDDP Cis-Platin

  • ADR Adriblastin

  • DTX Diphtheria Toxin


4. The Effect of Dilutions of Antigens and Various Biologic Factors on the Activity of Basophil Leukocytes
Dr. SAINTE-LAUDY (France), Professor MANNAIONNI (University of Florence, Italy), Professor ENNIS (Queen's University, Belfast)

The action of centesimal dilutions of various substances on several types of white blood cells has been under study since 1981. Polynuclear basophils are studied most often…

After publication of an article on basophil activation with high dilutions of anti-IgE, then the resultant investigation, it became difficult to publish on the inhibition of basophil activation with high dilutions.

 

4. Center for Complex Infectious Diseases
John Martin, M.D. Ph.D.
What are Stealth Viruses?

Viruses are submicroscopic infectious agents that replicate inside cells. Viral illnesses are normally controlled by the body’s immune system acting primarily through white blood cells called lymphocytes

Atypically-structured cell-damaging (cytopathic) viruses were initially identified in patients with the chronic fatigue syndrome and in patients with more severe neurological and neuropsychiatric illnesses. The term “stealth” was introduced to highlight their basic property of evading effective immune recognition, and also because they had gone unrecognized by the medical community.


 

Published Scientific Papers:

1. Published Research Projects in homeopathy:
 

Vittorio Elia and Marcella Niccoli
Thermodynamics of extremely diluted aqueous solutions.
Annals of the New York Academy of Sciences, June 1999
An extensive thermodynamic study has been carried out on aqueous solutions obtained through successive dilutions and succussions of 1% in weight of some solutes up to extremely diluted solutions, (less than 1x10-5 mol kg-1) obtained via several 1/100 successive dilution processes. The interaction of acids or bases with the extremely diluted solutions has been studied calorimetrically at 25°C. Measurements have been performed of the heats of mixing of acid or basic solutions, having different concentrations, with bidistilled water or with the extremely diluted solutions. Despite the extreme dilution of the solutions, an exothermic heat of mixing in excess has been found, in about the 92% of the cases, with respect to the corresponding heat of mixing with the untreated solvent. Here [it is shown] that successive dilutions and succussions may alter permanently the physical-chemical properties of the solvent water. The nature of the phenomena here described still remains unexplained, but significant experimental results are obtained.

 
Dittmann and G. Harisch
Characterization of Differing Effects Caused by Homeopathically Prepared and Conventional Dilutions Using Cytochrome P450 2E1 and Other Enzymes as Detection Systems
The journal of Alternative and Complementary Medicine 1996 2:2,279-290.
Target of investigation was to ascertain differences in the effects of homeopathic potencies (D) and equally concentrated conventional dilutions (V) on p-nitrocatechol formation catalyzed by CYP 2E1. Arsenicum album and potassium cyanatum (D) were compared to equivalent dilutions of As203 and KCN (V). Significant differences in enzyme activity were found. The difference of influence exists and this may be attributable to the manufacturing process of homeopathic drugs, namely, the stepwise dilution with intermediate agitation.


K. Linde, W.B. Jonas, D. Melchart, D., et al.,
Critical Review and Meta-Analysis of Serial Agitated Dilutions in Experimental Toxicology
Human and Experimental Toxicology, 1994, 13:481-92.
This meta-analysis of 105 studies in toxicology showed that homeopathic medicines may be useful in treating toxic exposures. This meta-analysis was conducted by a similar group of researchers who recently published a meta-analysis on clinical studies in The Lancet.


P.C. Endler, W. Pongratz, G. Kastberg, et al.,
The Effect of Highly Diluted Agitated Thyroxine on the Climbing Activity of Frogs
Veterinary and Human Toxicology, 1994, 36:56.
This, and the study below, show that a homeopathic medicine can influence the growth and development of tadpoles in water.


P.C. Endler, W. Pongratz, R. van Wijk, et al.,
Transmission of Hormone Information by Non-molecular Means
FASEB Journal, 1994, 8, Abs.2313.
This, and the study above, show that a homeopathic medicine can influence the growth and development of tadpoles in water.


J. Benveniste, P.C. Endler and J. Schulte, (eds.),
Further Biological Effects Induced by Ultra High Dilutions: Inhibition by a Magnetic Field," in Ultra High Dilution
Dordrecht: Kluwer Academic, 1994, 35.
This, and the study below, show that certain magnetic fields can neutralize the effects of a homeopathic medicine.
 

J. Benveniste, B. Arnoux, L. Hadji,
Highly Dilute Antigen Increases Coronary Flow of Isolated Hart from Immunized Guinea-pigs
FASEB Journal, 1992, 6:Abs.1610.
This, and the study above, show that certain magnetic fields can neutralize the effects of a homeopathic medicine.


E. Davenas, B. Poitevin, and J. Benveniste
Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica
European Journal of Pharmacology, April, 1987, 135:313-319.
This study showed Silica 6C and Silica 10C induced a statistically significant increase in immune function, as measured in macrophages in the blood of mice.

 

2. Published Clinical Trials on the Efficacy of Homeopathic Medicine:
 

C. N. Shealy, MD, R.P. Thomlinson, V. Borgmeyer,
Osteoarthritic Pain: A Comparison of Homeopathy and Acetaminophen
American Journal of Pain Management, 1998;8:89-91
A double-blinded study to document the relative efficacy of homeopathic remedies in comparison to acetaminophen for the treatment of pain associated with osteoarthritis (OA) among 65 patients. An IRB approved protocol. Results of the study documented better pain relief in the homeopathic group (55% achieved measured relief from homeopathy as compared to 38% from acetaminophen); however, the superiority of this treatment, in comparison with the acetaminophen group, did not reach statistical significance. The investigators conclude that homeopathic treatments for pain in OA patients appear to be safe and at least as effective as acetaminophen, and are without its potential adverse effects including compromise to both liver and kidney function. Many of the patients asked to continue with the homeopathic treatment.
 

M. Weiser, W. Strosser, P. Klein,
Homeopathic vs. Conventional Treatment of Vertigo: A Randomized Double-Blind Controlled Clinical Study
Archives of Otolaryngology--Head and Neck Surgery, August, 1998, 124:879-885.
This was a study with 119 subjects with various types of vertigo, half of whom were given a homeopathic medicine (a combination of four homeopathic medicines) and half were given a leading conventional drug in Europe for vertigo, betahistine hydrochloride. The homeopathic medicines were found to be similarly effective and significantly safer than the conventional control.
 

D. Reilly, M. Taylor, N. Beattie, et al.,
Is Evidence for Homoeopathy Reproducible?
Lancet, December 10, 1994, 344:1601-6.
This study successfully reproduced evidence from two previous double-blinded trials all of which used the same model of homeopathic immunotherapy in inhalant allergy. In this third study, 9 of 11 patients on homeopathic treatment improved compared to only 5 of 13 patients on placebo. The researchers concluded that either homeopathic medicines work or controlled studies don't. Their work has again be recently replicated and is submitted for publication. (See Is Homeopathy a Placebo Response? Lancet 1986, below.)
 

J. Jacobs, L. Jimenez, S. Gloyd,
Treatment of Acute Childhood Diarrhea with Homeopathic Medicine: A Randomized Clinical Trial in Nicaragua
Pediatrics, May 1994, 93,5:719-25.
This study was the first on homeopathy to be published in an American medical journal. The study compared individualized high potency homeopathic preparations against a placebo in 81 children, between ages 6 mo. and 5 yrs., suffering with acute diarrhea. The treatment group benefited from a statistically significant 15% decrease in duration. The authors noted that the clinical significance would extend to decreasing dehydration and postdiarrheal malnutrition and a significant reduction in morbidity.
 

E. Ernst, T. Saradeth, and K.L. Resch,
Complementary Treatment of Varicose Veins: A Randomized Placebo-controlled, Double-Blind Trial
Phlebology, 1990, 5:157-163.
This study of 61 patients showed a 44% improvement in venous filling time in the homeopathic treated group when compared with placebo.
 

P. Fisher, A. Greenwood, E.C. Huskisson, et al.,
Effect of Homoeopathic Treatment on Fibrositis
British Medical Journal, August 5, 1989, 299:365-66.
This trial was double-blind with a crossover design, comparing R toxicodendron to a placebo in 30 patients all suffering from an identical syndrome identified as the admission criteria. It showed a significant reduction in tender spots, by 25%, when patients were given the homeopathic medicine, as compared to when they were given the placebo.
 

D. Reilly, M. Taylor, C. McSherry,
Is Homeopathy a Placebo Response? Controlled Trial of Homeopathic Potency with Pollen in Hayfever as Model
Lancet, October 18, 1986, 881-86.
The double-blind study compared a high dilution homeopathic preparation of grass pollens against a placebo in 144 patients with active hay fever. The study method considered pollen counts, aggravation in symptoms and use of antihistamines and concluded that patients using homeopathy showed greater improvement in symptoms than those on placebo, and that this difference was reflected in a significantly reduced need for antihistamines among the homeopathically treated group. The results confirmed those of the pilot study and demonstrate that homeopathic potencies show effects distinct from those of the placebo

He responded to these criticisms point by point.

  • On the reproducibility of the phenomenon: a simple protocol permitted confirmation of the inhibiting activity of several dilutions of histamine, particularly 18 CH.

  • On the subjectivity of the method: an automated technique for measuring the activation of the basophils had been developed, based on the expression of a "marker" for this activation, determined by a flux cytometer. It recorded the inhibiting activity of 17 and 18 CH of histamine.